The healthy body creates free radicals as a result of normal activity & metabolism. These free radicals, known as ROS (reactive oxygen species) or RNS (reactive nitrogen species) are kept in check by the healthy body, maintaining normal mitochondrial function and minimizing oxidative stress. Health challenges may promote an unhealthy level of antioxidants. However, even professional athletes create higher oxidative stress levels than those who do not exercise to the same extreme. The point is that oxidative stress occurs on an ongoing basis.
Oxidative Stress Management1*
Aging and age-related diseases reflect the inability of our antioxidant defenses to cope with oxidative stress over time. Strong antioxidant defenses (endogenous & exogenous) are correlated with a healthier life1.*
Some Free Radicals (Oxidants) Are Good
It is important to note that not all oxidants are bad. We need oxidants such as nitric oxide to support our vascular system. We need oxidants for healthy cell signaling (intercellular communication). Phagocytes (special immune cells) deliberately release free radicals as a part of their chemical cocktail to kill & digest bacteria & viruses2
Under normal physiological conditions ROS/RNS exist at low cell concentrations that do not cause excessive cellular damage3.
Hydrogen Gas: A Selective Antioxidant*
New research has shown that Molecular Hydrogen (two atoms of hydrogen combined into one molecule – H2) is a powerful antioxidant that selectively targets the most toxic of free radicals*, the hydroxyl group4. The ability to selectively target free radicals is important as it means that it will not interfere with adjunctive therapies doctors may be pursuing. Unique features of hydrogen gas include:
- It only neutralizes bad free radicals, including the hydroxyl radical4*
- Diffuses across membranes, including mitochondria, due to its small size5*
- Hydrogen has the ability to effectively penetrate biomembranes and infiltrate into organelles, such as mitochondria and the nucleus3*
- In contrast to many antioxidants, H2 also has the advantage of being able to penetrate the blood-brain barrier3*
- H2 can be dissolved in water and it does not change the intracellular acidity, add taste, color or change in any way the characteristics of water3Once ingested, hydrogen-infused water passes quickly into the blood and throughout the body3*
- Promotes healthy lactic acid levels and post-exercise recovery in athletes3*
- Supports healthy inflammation levels3*
Since 2007, there have been over 60 significant published research studies:
- Hydrogen Gas – 21 published studies
- Hydrogen via Saline Injections – 27 published studies
- Hydrogen Water – 23 published studies
According to Garth Nicolson, PhD, “there are now a critical number of scientific and clinical studies that support the use of hydrogen as a primary or supportive component of clinical care”.
1 Studies on free radicals, antioxidants, and co-factors, Rahman, K., Clin Interv Aging. 2007 Jun; 2(2): 219–236.
2Mitochondrial production of reactive oxygen species contributes to the beta-adrenergic stimulation of mouse cardiomycytes, Andersson D, et al., The Journal of Physiology, 2011 Apr 1; 589(Pt 7): 1791–1801.
3Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine, Nicolson G. et al., International Journal of Clinical Medicine, 2016, 7, 32-76.
4Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals, Ikuroh Ohsawa, et al. Nature Medicine Vol 13, No. 6, June 2007.
5Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine, Ohta S., Pharmacology & Therapeutics, Volume 144, Issue 1, October 2014, Pages 1–11