Earthworm Protein Extract
Showing all 2 results
Boluoke® (lumbrokinase) is the only fully researched oral enzyme on the market supporting a healthier blood state, and it shows great promise in supporting a healthy coagulation/fibrinolysis balance in the body. Coagulation system is a complicated and highly regulated system. Modern lifestyles often tip the balance towards hypercoagulation (thick blood) and rarely towards hypocoagulation. For most people, Boluoke® can support the body in keeping the system in a more balanced state.
Lumbrokinase is a more potent enzyme preparation than nattokinase. One of the advantages of Boluoke® (lumbrokinase) is that it does not interfere with the clotting cascade, but instead, works by reducing fibrinogen and fibrin. Boluoke® does not affect INR or aPTT, thus is compatible with Coumadin® or heparin.
Boluoke® vs. Other Lumbrokinase Products
Comparing other lumbrokinase products to Boluoke® is like comparing apples and oranges. Boluoke®’s enzymatic strength is standardized against urokinase and t-PA. The imitation products are likely just earthworm protein extract containing little pure lumbrokinase or lumbrokinase of low enzymatic strength. Some companies are making products with 230mg to 250mg of lumbrokinase per capsule and trying to quote Boluoke®’s research as their own. Boluoke®’s capsules are of 200mg in size, and contain 20mg of lumbrokinase inside each capsule. Most of these other lumbrokinase are unable to distinguish between the weight of the capsule (i.e. 250 mg) and the active lumbrokinase per capsule (Boluoke® is 20 mg).
Boluoke® is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Boluoke® is the only Lumbrokinase that is backed by Phase I – III clinical trials in China, the one that is first used in hospitals in China, and covered by the Chinese National Fundamental Health Insurance.
A common question we receive is about potential side effects of Boluoke®. The earthworm has been used in Traditional Chinese Medicine for a few thousand years, and is considered to be one of the safest medicines in the traditional pharmacopoeias. In one of the largest clinic trials of Boluoke® involving 16 hospitals and 1560 patients in China, the overall adverse reaction rate was 1.92% (30 cases). 0.58% had skin itching, 0.19% had skin rash, and 1.15% had nausea or diarrhea; no hemorrhage or major side effect was reported. Again, this research pertains only to Boluoke®.
It is interesting that other lumbrokinase products cite the clinical results achieved with only Boluoke®, confusing the reader into assuming that the research was done on their formulations. However, their products may be very different, and your patients may have very different results.
On the raw material market, the price of lumbrokinase can vary by up to 15 fold, and the enzymatic strengths of various Lumbrokinase also differ greatly. In addition, lumbrokinase is a preparation containing multiple enzyme fractions, and the extraction and purification method determines the composition of the various enzyme fractions. Thus different extraction methods will produce different sub-fractions of lumbrokinase. This is the reason why Boluoke® does not significantly change prothrombin time (PT) or activated partial thromboplastin time (aPTT), while other lumbrokinase sources may significantly alter PT or aPTT as shown in studies. No other lumbrokinase product can provide you with this assurance.
Read the ResearchPurchase BioDisrupt®
BioDisrupt® supports the healthy immune system’s ability to target the sophisticated self-defense mechanisms of biofilms.* BioDisrupt® is a clinically researched formula featuring two proprietary blends: EnzymeDisrupt™ and HerbDisrupt™. These blends work synergistically to provide comprehensive microbial biofilm support by disrupting the biofilm matrix and inhibiting the formation of new biofilms.*Read the researchPurchase ATP 360®
ATP360® is a comprehensive mitochondrial support formula utilizing powerful ingredients to provide targeted support.
Clinical human research has been peer-reviewed and published in Alternative Therapies May/Jun 2021 Vol. 27 No. 3
This human study demonstrated significant improvements in energy in as little as 2 weeks.* Additional study results showed ATP360’s® ability to support sleep and healthy cardiovascular function.*[2]
Read the researchPurchase Tri-Fortify®
Tri-Fortify® is a delicious tasting, heat stable (no refrigeration required) oral liposomal glutathione supplement with clinically proven absorption.
Penn State University conducted a 2-week human study using Tri-Fortify® to assess changes in intracellular glutathione absorption (not just plasma levels). Researchers also looked at natural killer cell function and oxidative stress markers.
The study showed a 28% increases in intracellular glutathione levels after just 2 weeks of use, as well as demonstrating its ability to support healthy NK cell function and oxidative stress levels.*¹
[1] Sinha R, Sinha I, Calcagnotto A, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018;72(1):105-111. doi:10.1038/ejcn.2017.132
Read the researchLearn More About Transfer Factor Multi-Immune™
Transfer Factor Multi-Immune™ is an advanced immune support formula comprising a proprietary blend of bovine derived transfer factors and whole colostrum, along with multiple immune supporting herbs, and mushrooms.
Multiple clinical studies on Transfer Factor Multi-immune™ have demonstrated substantial increases in Natural Killer cell function, as well as the ability to support immune modulation.*
¹Jensen GS, Cruickshank D, Hamilton DE. Effects of a β-Glucan-Rich Blend of Medicinal Mushrooms and Botanicals on Innate Immune Cell Activation and Function Are Enhanced by a Very Low Dose of Bovine Colostrum Peptides. Molecules. 2024 Jun 12;29(12):2787. doi: 10.3390/molecules29122787.
Read the researchPurchase CytoQuel®
CytoQuel®, backed by peer-reviewed research published in the Journal of Pain Research, is a comprehensive blend to promote healthy cytokine function.*
In an 8-week human clinical study, CytoQuel® showed statistically significant evidence of its ability to support healthy cytokine function. The Study indicated CytoQuel’s® ability to promote healthy cardiovascular function, support improved quality of sleep, and promote normal MMP-9 levels. [3]
[3] Hamilton DE, Jensen GS. Pain reduction and improved vascular health associated with daily consumption of an anti-inflammatory dietary supplement blend. J Pain Res. 2019 May 15;12:1497-1508. doi: 10.2147/JPR.S189064. PMID: 31190960; PMCID: PMC65267
Read the ResearchLearn More About BDNF Essentials®
BDNF Essentials® is a comprehensive formula designed to support neurological health and cognitive function. This unique formula leverages ingredients that have been shown to aid in the formation of nerve growth factors such as BDNF (Brain-derived neurotrophic factor). BDNF is essential in supporting neuron health, neuroplasticity, and neurogenesis.
Clinical research demonstrated that BDNF Essentials® significantly improved reaction time in measures of working memory, episodic memory (long-term memory of specific events or episodes), and attention, as well as in mood.*
Research also indicated reduced salivary cortisol and IL-6. These data suggest the use of BDNF Essentials® to support the age-related decline in cognitive function and memory.*
[1] Lewis D. Erin, Crowley C. David, Hamilton Debby, Guthrie Najla and Evans Malkanthi*, An Open-label Exploratory Study Investigating BDNF Essentials® on Cognition in Healthy Adults with Self-reported Memory Complaints, Current Nutraceuticals 2023; 4 : e171123223619 . https://dx.doi.org/10.2174/0126659786256669230930114915
