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The importance of healthy sleep for overall health and well-being cannot be overstated. Unfortunately, achieving quality sleep is a challenge for many people. Common biological contributors to poor sleep can include physical discomfort, stress, anxiety, high histamine levels, and low levels of sleep-promoting neurotransmitters, such as gamma-aminobutyric acid (GABA).[1]
A multifaceted approach is needed to support falling asleep faster, staying asleep longer, and achieving higher quality, more restful sleep. Circadian PM™ utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep.
Circadian PM™ features PharmaGABA®, the natural form of GABA, made through a natural fermentation process. This results in a superior form of GABA vs other synthetic options. Synthetic forms of GABA are less bio-available, as their molecular size is too large to pass the blood-brain barrier. PharmaGABA® is easily absorbed and binds to GABA receptors in the peripheral nervous system, activating the parasympathetic nervous system. This activation of the parasympathetic nervous system by PharmaGABA® is measurable within 5 to 30 minutes after ingestion .*
The unique blend of herbs, nutrients, and amino acids make Circadian PM™ a must-have formulation for patients dealing with sleep challenges and those who want to improve the quality of their sleep utilizing natural methods.
| Features | Constituents/Actions | Benefits* |
| CalmNight Blend™ | Glycine, Valerian Extract (Valeriana officinalis) (root), CurcuWIN™ Turmeric Extract, Lemon Balm Extract (Melissa officinalis) (leaf), Magnolia Extract (Magnolia officinalis) (bark), 5 HTP (5-hydroxytryptophan), L-theanine, PharmaGABA® (gamma-aminobutyric acid) | • Supports NREM Stage 1 for sleep initiation* • Nurtures restfulness to help maintain length of time asleep* • Promotes the transition between NREM Stages (1-3), preparing the brain and body for deeper, restorative sleep* • Supports REM, the most important sleep state, allowing the body to repair and restore itself* • Anxiolytic and calming ingredients support GABA levels, as well as serotonin – a precursor to the natural production of melatonin, an essential hormone for quality sleep* • Promotes healthy mental and physical relaxation to reduce wakefulness and restlessness* • Supports normal cytokine function to relax the central nervous system and support physical discomfort* |
| HistaCalm™ | Black Cumin Extract (Nigella sativa) (seed), Stinging Nettle Extract (leaf) | • Promotes a healthy level of histamine to bind to its receptors by competitive inhibition* • Reduces wakefulness by supporting healthy histamine levels in the brain* |
[1] The contributing factors to poor sleep experiences in according to the university students: A cross-sectional study Altun I et al. J Res Med Sci. 2012 Jun; 17(6): 557–561.
Notice: Due to VAT laws in the UK and our agreement with our European distributor, we are not able to ship orders to the UK. Please contact www.nutrined.com to complete your purchase.
Read the ResearchPurchase BioDisrupt®
BioDisrupt® supports the healthy immune system’s ability to target the sophisticated self-defense mechanisms of biofilms.* BioDisrupt® is a clinically researched formula featuring two proprietary blends: EnzymeDisrupt™ and HerbDisrupt™. These blends work synergistically to provide comprehensive microbial biofilm support by disrupting the biofilm matrix and inhibiting the formation of new biofilms.*Read the researchPurchase ATP 360®
ATP360® is a comprehensive mitochondrial support formula utilizing powerful ingredients to provide targeted support.
Clinical human research has been peer-reviewed and published in Alternative Therapies May/Jun 2021 Vol. 27 No. 3
This human study demonstrated significant improvements in energy in as little as 2 weeks.* Additional study results showed ATP360’s® ability to support sleep and healthy cardiovascular function.*[2]
Read the researchPurchase Tri-Fortify®
Tri-Fortify® is a delicious tasting, heat stable (no refrigeration required) oral liposomal glutathione supplement with clinically proven absorption.
Penn State University conducted a 2-week human study using Tri-Fortify® to assess changes in intracellular glutathione absorption (not just plasma levels). Researchers also looked at natural killer cell function and oxidative stress markers.
The study showed a 28% increases in intracellular glutathione levels after just 2 weeks of use, as well as demonstrating its ability to support healthy NK cell function and oxidative stress levels.*¹
[1] Sinha R, Sinha I, Calcagnotto A, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018;72(1):105-111. doi:10.1038/ejcn.2017.132
Read the researchLearn More About Transfer Factor Multi-Immune™
Transfer Factor Multi-Immune™ is an advanced immune support formula comprising a proprietary blend of bovine derived transfer factors and whole colostrum, along with multiple immune supporting herbs, and mushrooms.
Multiple clinical studies on Transfer Factor Multi-immune™ have demonstrated substantial increases in Natural Killer cell function, as well as the ability to support immune modulation.*
¹Jensen GS, Cruickshank D, Hamilton DE. Effects of a β-Glucan-Rich Blend of Medicinal Mushrooms and Botanicals on Innate Immune Cell Activation and Function Are Enhanced by a Very Low Dose of Bovine Colostrum Peptides. Molecules. 2024 Jun 12;29(12):2787. doi: 10.3390/molecules29122787.
Read the researchPurchase CytoQuel®
CytoQuel®, backed by peer-reviewed research published in the Journal of Pain Research, is a comprehensive blend to promote healthy cytokine function.*
In an 8-week human clinical study, CytoQuel® showed statistically significant evidence of its ability to support healthy cytokine function. The Study indicated CytoQuel’s® ability to promote healthy cardiovascular function, support improved quality of sleep, and promote normal MMP-9 levels. [3]
[3] Hamilton DE, Jensen GS. Pain reduction and improved vascular health associated with daily consumption of an anti-inflammatory dietary supplement blend. J Pain Res. 2019 May 15;12:1497-1508. doi: 10.2147/JPR.S189064. PMID: 31190960; PMCID: PMC65267
Read the ResearchLearn More About BDNF Essentials®
BDNF Essentials® is a comprehensive formula designed to support neurological health and cognitive function. This unique formula leverages ingredients that have been shown to aid in the formation of nerve growth factors such as BDNF (Brain-derived neurotrophic factor). BDNF is essential in supporting neuron health, neuroplasticity, and neurogenesis.
Clinical research demonstrated that BDNF Essentials® significantly improved reaction time in measures of working memory, episodic memory (long-term memory of specific events or episodes), and attention, as well as in mood.*
Research also indicated reduced salivary cortisol and IL-6. These data suggest the use of BDNF Essentials® to support the age-related decline in cognitive function and memory.*
[1] Lewis D. Erin, Crowley C. David, Hamilton Debby, Guthrie Najla and Evans Malkanthi*, An Open-label Exploratory Study Investigating BDNF Essentials® on Cognition in Healthy Adults with Self-reported Memory Complaints, Current Nutraceuticals 2023; 4 : e171123223619 . https://dx.doi.org/10.2174/0126659786256669230930114915
