Nettle (leaf)
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The importance of healthy sleep for overall health and well-being cannot be overstated. Unfortunately, achieving quality sleep is a challenge for many people. Common biological contributors to poor sleep can include physical discomfort, stress, anxiety, high histamine levels, and low levels of sleep-promoting neurotransmitters, such as gamma-aminobutyric acid (GABA).[1]
A multifaceted approach is needed to support falling asleep faster, staying asleep longer, and achieving higher quality, more restful sleep. Circadian PM™ utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep.
Circadian PM™ features PharmaGABA®, the natural form of GABA, made through a natural fermentation process. This results in a superior form of GABA vs other synthetic options. Synthetic forms of GABA are less bio-available, as their molecular size is too large to pass the blood-brain barrier. PharmaGABA® is easily absorbed and binds to GABA receptors in the peripheral nervous system, activating the parasympathetic nervous system. This activation of the parasympathetic nervous system by PharmaGABA® is measurable within 5 to 30 minutes after ingestion .*
The unique blend of herbs, nutrients, and amino acids make Circadian PM™ a must-have formulation for patients dealing with sleep challenges and those who want to improve the quality of their sleep utilizing natural methods.
| Features | Constituents/Actions | Benefits* |
| CalmNight Blend™ | Glycine, Valerian Extract (Valeriana officinalis) (root), CurcuWIN™ Turmeric Extract, Lemon Balm Extract (Melissa officinalis) (leaf), Magnolia Extract (Magnolia officinalis) (bark), 5 HTP (5-hydroxytryptophan), L-theanine, PharmaGABA® (gamma-aminobutyric acid) | • Supports NREM Stage 1 for sleep initiation* • Nurtures restfulness to help maintain length of time asleep* • Promotes the transition between NREM Stages (1-3), preparing the brain and body for deeper, restorative sleep* • Supports REM, the most important sleep state, allowing the body to repair and restore itself* • Anxiolytic and calming ingredients support GABA levels, as well as serotonin – a precursor to the natural production of melatonin, an essential hormone for quality sleep* • Promotes healthy mental and physical relaxation to reduce wakefulness and restlessness* • Supports normal cytokine function to relax the central nervous system and support physical discomfort* |
| HistaCalm™ | Black Cumin Extract (Nigella sativa) (seed), Stinging Nettle Extract (leaf) | • Promotes a healthy level of histamine to bind to its receptors by competitive inhibition* • Reduces wakefulness by supporting healthy histamine levels in the brain* |
[1] The contributing factors to poor sleep experiences in according to the university students: A cross-sectional study Altun I et al. J Res Med Sci. 2012 Jun; 17(6): 557–561.
Notice: Due to VAT laws in the UK and our agreement with our European distributor, we are not able to ship orders to the UK. Please contact www.nutrined.com to complete your purchase.
